منابع مشابه
A Gene Therapy Approach for Treating Muscle Degeneration in Neuromuscular Disorders Using IGF-I Splice Variants
N eurom uscular disorders, which associate with muscle degeneration, are not rare and affect millions o f people worldwide. The impacts o f such disorders vary from gradual loss o f mobility and independence to severe disability and death, and therefore m illions o f patients suffer from them at every stage o f their life. Because, there is currently no treatment o f any form o f such disorders...
متن کاملInsulin-like growth factor-I (IGF-I) and IGF binding protein-5 in Schwann cell differentiation.
Schwann cells (SCs) are the myelin producing cells of the peripheral nervous system. During development, SCs cease proliferation and differentiate into either a myelin-forming or non-myelin forming mature phenotype. We are interested in the role of insulin-like growth factor-I (IGF-I) in SC development. We have shown previously SCs proliferate in response to IGF-I in vitro. In the current study...
متن کاملAmniotic IGF-I supplements improve gut growth but reduce circulating IGF-I in growth-restricted fetal sheep.
Insulin-like growth factor I (IGF-I) is an important regulator of fetal growth, and circulating concentrations are reduced in intrauterine growth-restricted (IUGR) fetuses. We investigated whether IGF-I administered into amniotic fluid could ameliorate IUGR in fetal sheep. Fetuses were assigned to control (n = 9), IUGR+saline (n = 12), or IUGR+IGF-I groups (daily intra-amniotic IGF-I injections...
متن کاملInsulin-like growth factor-I (IGF-I) and clinical nutrition.
IGF-I (insulin-like growth factor-I) is a peptide hormone, produced predominantly by the liver in response to pituitary GH (growth hormone), which is involved in a wide variety of physiological processes. It acts in an endocrine, paracrine and autocrine manner to promote growth. The production of IGF-I signals the availability of nutrients needed for its anabolic actions. Recently, there has be...
متن کامل[Insulin-like growth factor I (IGF-I) and liver cirrhosis].
Insulin-like growth factor I (IGF-I) is a polypeptide hormone secreted by multiple tissues in response to growth hormone (GH). It is partly responsible for GH activity, and also has glucose-lowering and anabolizing effects. Ninety percent of circulating IGF-I originates in the liver and has autocrine, paracrine, and endocrine effects, the latter on multiple tissues. Liver cirrhosis results in a...
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ژورنال
عنوان ژورنال: European Journal of Endocrinology
سال: 2007
ISSN: 0804-4643,1479-683X
DOI: 10.1530/eje-07-0187